Author(s): Tischler J, Lehner B, Fraser AG
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Abstract Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans.
This article was published in Nat Genet
and referenced in Journal of Next Generation Sequencing & Applications