alexa Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release.


Medicinal Chemistry

Author(s): You J, Zhang G, Li C

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Abstract We report dual-functional hollow gold nanospheres (HAuNS, approximately 40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63\% DOX by weight ( approximately 1.7 microg DOX/microg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.
This article was published in ACS Nano and referenced in Medicinal Chemistry

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