alexa Exhaustive physical exercise increases frequency of micronuclei.


Journal of Clinical Toxicology

Author(s): Schiffl C, Zieres C, Zankl H

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Abstract Micronucleus (MN) tests were performed on PHA-stimulated blood lymphocytes of six healthy volunteers before and after two exhaustive sprints, causing lactate concentrations in the peripheral blood between 9.6 and 12.4 mmol/l. The number of micronuclei was significantly increased after 24-48 h in all six subjects. The mean of the total group increased from 37 MN per 3000 binucleated cells before exercise to 56 and 55 MN 24 and 48 h after exercise, respectively. These differences were also significant. These results indicate that exhaustive physical exercise causes severe mutations at the chromosome level in blood lymphocytes.
This article was published in Mutat Res and referenced in Journal of Clinical Toxicology

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