alexa Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice.
Neurology

Neurology

Journal of Neurology & Neurophysiology

Author(s): Wolf SD, Dittel BN, Hardardottir F, Janeway CA Jr, Wolf SD, Dittel BN, Hardardottir F, Janeway CA Jr

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Abstract Experimental autoimmune encephalomyelitis (EAE) is an animal model for autoimmune central nervous system disease mediated by CD4 T cells. To examine the role of B cells in the induction of EAE, we used B10.PL (I-Au) mice rendered deficient in B cells by deletion of their mu chain transmembrane region (B10.PLmicroMT). By immunizing B10.PL and B10.PLmicroMT mice with the NH-terminal myelin basic protein encephalitogenic peptide Ac1-11, we observed no difference in the onset or severity of disease in the absence of mature B cells. There was, however, a greater variation in disease onset, severity, and especially of recovery in the B cell-deficient mice compared to controls. B10.PLmicroMT mice rarely returned to normal in the absence of B cells. Taken together, our data suggest that B cells do not play a role in the activation of encephalitogenic T cells, but may contribute to the immune modulation of acute EAE. The mechanisms to explain these effects are discussed.
This article was published in J Exp Med and referenced in Journal of Neurology & Neurophysiology

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