alexa Experimental comparative evaluation of the functional capacities of ectopically grown foetal organs.


Journal of Transplantation Technologies & Research

Author(s): Coulic V, DeKoster E, Delre P, Deltenre P, DePrez C

Abstract Share this page

The interest for fetal organ, tissue, and cell implantation as therapeutic means in the treatment of some diseases is presently increasing. Hence, the aim of the present investigation was the comparative evaluation of the functional potential of ectopically grown fetal organs of different (ecto-, meso- and endodermic) origins. Unified operative model was the fetal organ fragment implantation into an ear subcutaneous pouch (without restoration of vascular and nervous links of the implant with the recipient organism). The implant isolation in vitro varied from 15 to 50 min. As control, intact animals and animals with streptozotocin diabetes and hepatic lesions due to the main bile duct ligature, were used. The implanted and ectopically grown fetal organs, though of different origins, developed functional activity. The best adult-like function was obtained in intestinal, gastric and cardiac implants, i.e. in organs with a cavity and a well developed self-regulation system. Poorer results were obtained in great digestive glandular implants--pancreas and liver. In the best cases when the implant function was very closed to the adult organ, a difference nevertheless was observed. The model of ectopic implantation of fetal organs may be useful for study of the organ and tissue function ontogenesis (up to the moment of natural ageing involution), for the evaluation of different isolated factor influence on organ and tissue physiology and pathology. Although being optimistic in respect to clinical application of fetal organ and cell implantation, this study does not prevent us from being cautions.

  • To read the full article Visit
  • Subscription
This article was published in Russ J Physl and referenced in Journal of Transplantation Technologies & Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version