alexa Experimental metastasis is suppressed in MMP-9-deficient mice.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Itoh T, Tanioka M, Matsuda H, Nishimoto H, Yoshioka T,

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Abstract Matrix metalloproteinases (MMPs) are thought to play a key role in tumor invasion and metastasis. The role of MMP-9 (gelatinase B) in tumor metastasis was examined in MMP-9-deficient mice produced by gene targeting using embryonic stem cells. MMP-9-deficient mice develop normally and are fertile. In these mice, the number of metastatic colonies of B16-BL6 melanoma cells or Lewis lung carcinoma cells that were implanted intravenously fell by 45\% for B16-BL6 melanoma and 59\% for Lewis lung carcinoma (p = 0.03 and p = 0.0043, respectively). Gelatin zymography showed that both tumor cell lines did not secrete MMP-9 by themselves but the host cells surrounding the tumor cells secrete MMP-9 in vivo. These results indicated that host-derived MMP-9 plays an important role in the process of tumor metastasis.
This article was published in Clin Exp Metastasis and referenced in Journal of Cytology & Histology

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