alexa [Experimental study of contraction loss effects of mouth mucosa by ethanol injection].
Immunology

Immunology

Journal of Allergy & Therapy

Author(s): Wu MD, Taguchi A, Kimura M, Inafuku S

Abstract Share this page

Abstract We began treating patients with simple snoring and obstructive sleep apnea syndrome (OSAS) with the coblator radiofrequency generator in our outpatient clinic from April 2001. Good clinical results have been obtained, but we noticed a contractile effect on mucosa from ethanol, which possesses marked sclerotic degenerative action on tissue as well as radiofrequency energy. We conducted a series of experiments in a guinea pig model to investigate the efficacy of local ethanol injection in contracting mouth mucosa. To examine the influence on respiration of liquid injection, physiological saline was gradually injected in decrements into the arch of the palate mucosa. We found that the safe dosage that did not bring about edema and subsequent dyspnea was under 10 microliters. Based on this finding, ethanol in concentrations of 50\%, 70\%, and 100\% at volumes of 1, 2, 4, 8, and 10 microliters was injected into the arch of the palate mucosa in guinea pigs and changes in local field mucosa were observed daily. In the 50\% ethanol injection, no clear contractile effect on mucosa could be observed at any dosage. In contrast, the 100\% ethanol injection led to strong tissue impairment that caused extensive necrotic collapse of the local field mucosa, even when the dosage was down to the minimum of 1 microliter. We found that, injection of 70\% ethanol at 1 or 2 microliters, however, resulted in formation of a local field mucosa wound of lesser degree that healed completely within a few days, associated with moderate contraction of mucosal tissue. We concluded that in moderate dosage, 70\% ethanol seems to have the potential for the treatment of endermosis, such as uvuloptosia (elongated uvula) and hypertrophy of palate mucosa, as a useful mucosa contractile agent.
This article was published in Nihon Jibiinkoka Gakkai Kaiho and referenced in Journal of Allergy & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords