alexa Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
Chemistry

Chemistry

Organic Chemistry: Current Research

Author(s): Collin F, Karkare S, Maxwell A

Abstract Share this page

Abstract DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher eukaryotes, making it an attractive target for antibacterials. The fluoroquinolones are examples of very successful gyrase-targeted drugs, but the rise in bacterial resistance to these agents means that we not only need to seek new compounds, but also new modes of inhibition of this enzyme. We review known gyrase-specific drugs and toxins and assess the prospects for developing new antibacterials targeted to this enzyme.
This article was published in Appl Microbiol Biotechnol and referenced in Organic Chemistry: Current Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 3rd International Conference on Organic & Inorganic Chemistry
    July 17-19, 2017 Chicago, Illinois, USA
  • 3rd World Chemistry Conference
    September 11-12, 2017 Dallas, USA
  • 2nd International Conference on Biochemistry
    Sep 21-22, 2017 Macau, Hong Kong
  • Chemistry Congress 2017
    October 02-04, 2017 Vancouver, Canada

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords