alexa Exploiting chromosomal and viral strategies: the design of safe and efficient non-viral gene transfer systems.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Lipps HJ, Bode J

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Abstract The development of gene transfer systems for therapeutic applications depends, to a large part, on an understanding of chromosomal elements mediating controlled gene expression, and DNA synthesis and maintenance. The integration of transgenes into chromosomes assures their faithful replication and segregation due to the natural functions of the host chromosome, but their expression is susceptible to inactivation by the host-cell apparatus, and they may also cause unwanted mutagenic effects. While episomal vectors are free from these shortcomings, progress in this field suffers from the lack of an in-depth understanding of the accessory functions, although a number of first-generation prototypes have been constructed in the past years. As an immediate solution, small non-viral circular episomal vectors are emerging which not only permit the study of the relevant components in a minimal gene-transfer system, but for which a considerable potential for therapeutic applications can be anticipated.
This article was published in Curr Opin Mol Ther and referenced in Journal of Cell Science & Therapy

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