Author(s): Li T, Liu D, Zhang F
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Abstract OBJECTIVE: To investigate the molecular basis of the high aggressiveness of nasal NK/T cells lymphoma. METHODS: Immunohistochemical study was used on 17 cases of nasal NK/T cells lymphoma to examine CD20, CD43/CD45RO, CD3, CD56, TIA-1, and CD44. In situ hybridization was used to examine Epstein-Barr virus (EBV) infection, VEGF, and bFGF. RESULTS: The positive rates of CD20, CD43/CD45RO, CD3, CD56, TIA-1, and CD44 were 0\%, 88.2\%, 70.6\%, 88.2\%, 100\%, and 41.2\%. Fifteen cases (88.2\%) were positive in EBER1 (EBV infection). VEGF was expressed in 11 cases (64.7\%). VEGF expression was negative in 2 out of 4 cases with angioinvasion, and negative in 4 cases out of 7 cases who died of tumor. bFGF was weakly expressed in 3 cases (17.6\%) and was not expressed in 2 out of 4 cases with angioinvasion and 6 out of 7 cases who died of tumor. CD44 expression was negative in all 3 cases with dysplasia, and in 4 out of the 7 cases who died of tumor. CONCLUSION: CD44 can not predict the potentiality of NK/T cells lymphoma in invasion, and does not correlate with prognosis. The expression of VEGF is far more frequent than that of bFGF in NK/T cells lymphoma. The significance of VEGF and bFGF expression remains to be investigated.
This article was published in Zhonghua Yi Xue Za Zhi
and referenced in Journal of Blood Disorders & Transfusion