alexa Expression and significance of HIF-1 α and VEGF in rats with diabetic retinopathy.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Yan HT, Su GF

Abstract Share this page

Abstract OBJECTIVE: To investigate the expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in diabetic retinopathy (DR) rats and its effect on the DR occurrence and development. METHODS: A total of 120 SD rats were randomly divided into trial group and control group with 60 in each. STZ i.p. was used in the trial group to establish the DM model, citrate buffer salt of same amount was used i.p. to the control group. 1, 3 and 6 months after injection, respective 20 rats were sacrificed in each group to observe expression of HIF-1α and VEGF in the rat retina tissue at different time points. RESULTS: Expression of HIF-1α and VEGF were negative in the control group; expression of HIF-1α and VEGF protein in retinal tissue were weak after 1 month of DR mold formation. It showed progressive enhancement along with the progression in different organizations, differences between groups were significant (P<0.05). CONCLUSIONS: Expressions of HIF-1α and VEGF were correlated with disease progression in early diabetic retinopathy. Retinal oxygen can induce over-expression of HIF-1α and VEGF. It shows that HIF-1α and VEGF play an important role in the pathogenesis of DR. Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved. This article was published in Asian Pac J Trop Med and referenced in Journal of Molecular and Genetic Medicine

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords