alexa [Expression of CYR61 and VEGF in extranodal nasal-type NK T cell lymphoma and their significances].
Haematology

Haematology

Journal of Blood Disorders & Transfusion

Author(s): Tang QL, Liu WP, Zhang WY, Yang F, He MX,

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Abstract OBJECTIVE: To investigate the expression of CYR61 and VEGF in extranodal nasal-type NK/T cell lymphoma and its significance. METHODS: CYR61 mRNA and VEGF mRNA were detected by real-time fluorescence quantitative PCR method in 20 cases of extranodal nasal-type NK/T cell lymphoma. Expressions of CYR61 and VEGF were studied by immunohistochemistry in 40 cases of the tumor. RESULTS: (1) Over-expression of CYR61 mRNA and VEGF mRNA was found in 19/20(95.0\% ) and 15/20(75.0\% ) cases, respectively. (2)Tumor cells expressing CYR61 protein and VEGF protein were detected in 38(95.0\% ) and 25 (62. 5\% ) of the 40 cases respectively, being no significant difference from the control. Co-expression of CYR61 and VEGF at both the mRNA and protein levels was 95.0\% and 65.0\% , respectively. Over-expression of CYR61 and VEGF at both mRNA and protein levels was found in 8 of the 40 cases. (3) The prognosis of the patients over-expressing CYR61 and VEGF was worse. CONCLUSION: In extranodal nasal-type NK/T cell lymphoma, the expression level of CYR61 and VEGF was changed and it may be of prognostic implication of
This article was published in Zhonghua Xue Ye Xue Za Zhi and referenced in Journal of Blood Disorders & Transfusion

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