alexa Expression of hexokinase II and Glut-1 in untreated human breast cancer.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Current Synthetic and Systems Biology

Author(s): Brown RS, Goodman TM, Zasadny KR, Greenson JK, Wahl RL

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Abstract Expressions of HKII and Glut-1 were studied in untreated primary human breast cancers by immunohistochemistry. 79\% of the breast cancers were HKII-positive and 61\% were Glut-1-positive. Average positive malignant cell areas were 66 +/- 41\% for HKII and 29 +/- 36\% for Glut-1. HKII staining was cytoplasmic, suggesting mitochondrial localization with no variations in staining intensities. Glut-1 staining was heterogeneous, cytoplasmic and membranous and varied with histology and tumor stage. Cells expressing HKII did not always express Glut-1 and vice versa. Increased FDG-uptake appeared to be associated with increased Glut-1 expression (P = 0.021), but not with HKII expression (p = 0.6).FDG uptake in breast cancer tissue appears to be associated with the extent of immunodetectable expression of Glut-1, but not that of HKII, and FDG uptake may differ between individual tumors depending on tumor stage and histology.
This article was published in Nucl Med Biol and referenced in Current Synthetic and Systems Biology

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