alexa Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing vitamin E diffusion barriers.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Peng CC, Kim J, Chauhan A

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Abstract This paper proposes an approach for increasing drug release durations from contact lenses and other biomedical devices by in situ creation of transport barriers of Vitamin E that force drug molecules to diffuse through long tortuous path. Results show that the increase in release duration is quadratic in Vitamin E loading, which is consistent with proposed mathematical models. Loadings of 10 and 40\% Vitamin E increase release time of timolol by a factor of about 5 and 400, respectively for NIGHT&DAY lens. Similar results have been obtained for other hydrophilic drugs including fluconazole and dexamethasone 21-disodium phosphate (DXP). Vitamin E loading in the NIGHT&DAY lens leads to slight increase in lens sizes (6.5\% increase for 30\% loading), a slight reduction in oxygen diffusion (about 40\% reduction for 75\% loading), and a more significant reduction in the ion permeability (50\% reduction for 10\% loading). Additionally, Vitamin E loading has a beneficial effect of blocking UV radiation which will reduce the corneal damage due to UV light. Copyright 2010 Elsevier Ltd. All rights reserved. This article was published in Biomaterials and referenced in Journal of Clinical & Experimental Pharmacology

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