alexa Extracellular Ubiquitin Regulates the Growth of Human Hematopoietic Cells


Journal of Molecular Histology & Medical Physiology

Author(s): Hanako Daino, Hirohiko Shibayama, Takashi Machii, Teruo Kitani

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We investigated the effects of extracellular ubiquitin on the colony formation of human hematopoietic progenitor cells (CFU-GM, CFU-E and BFU-E) and a granulocyte-colony stimulating factor (G-CSF)-dependent human myeloblastic leukemic cell line, OCI/AML/1a. Ubiquitin exhibited inhibitory effects on CFU-GM, CFU-E, BFU-E and OCI/AML/1a colony formation. Extracellular ubiquitin also inhibited the growth of KT3 (T lymphoblast), K562 (erythroleukemia) and Daudi (Burkitt's lymphoma) cells, stimulated the growth of HL60 (promyelocytic leukemia) and Jurkat (T-ALL) cells and showed no effect on the growth of U937 cells (monocytic leukemia). These results indicate that another, previously unrecognized function of extracellular ubiquitin is to regulate hematopoiesis.

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This article was published in Biochemical and Biophysical Research Communications and referenced in Journal of Molecular Histology & Medical Physiology

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