alexa Extreme leucocytosis and the risk of serious bacterial infections in febrile children.


Journal of Medical Diagnostic Methods

Author(s): Brauner M, Goldman M, Kozer E, Brauner M, Goldman M, Kozer E

Abstract Share this page

Abstract OBJECTIVE: To determine the clinical significance of extreme leucocytosis (white blood cell (WBC) count >25,000/mm(3)) as a predictor of serious bacterial infection (SBI) in children. PATIENTS AND METHODS: A retrospective case-control study was conducted in a paediatric emergency department in Israel. The study evaluated children aged 3-36 months admitted to the emergency department with fever (>38 degrees C) who had a complete blood count (CBC). Children with extreme leucocytosis were identified through the laboratory database. Further, for each case patient two consecutive febrile patients with WBC counts of 15,000-24,999/mm(3) (moderate leucocytosis) served as controls (a case-control ratio of 1:2). RESULTS: During the study, 146 patients with extreme leucocytosis were identified and compared with 292 patients with moderate leucocytosis. SBI was found in 57 (39\%) patients with extreme leucocytosis compared with 45 (15.4\%) control patients (p<0.001). The most commonly found SBI was segmental or lobar pneumonia, which was diagnosed in 41 (28\%) patients in the case group compared with 27 (9.2\%) patients in the control group (p<0.001, OR 3.83, 95\% CI 2.25 to 6.52). Children with extreme leucocytosis were more often treated with antibiotics (52.7\% vs 27.7\%, p<0.001) and admitted to hospital (98.6\% vs 50.68\%, p<0.001). CONCLUSIONS: In febrile children aged 3-36 months, the presence of extreme leucocytosis is associated with a 39\% risk of having SBIs. The increased risk for SBI is mainly due to a higher risk for pneumonia. This article was published in Arch Dis Child and referenced in Journal of Medical Diagnostic Methods

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version