alexa Extremes of endogenous testosterone are associated with increased risk of incident coronary events in older women.
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Laughlin GA, Goodell V, BarrettConnor E

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Abstract CONTEXT: Few studies have examined whether endogenous testosterone is associated with the development of coronary heart disease (CHD) in women. OBJECTIVE: This study tested the association of total testosterone (total T) and bioavailable T (BioT) levels with risk of incident coronary events among older community-dwelling women. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, population-based study of 639 postmenopausal women, aged 50-91 (mean, 73.8) yr who had serum testosterone measurements at baseline (1984-87) and who were followed for incident CHD events through 2004. MAIN OUTCOME MEASURES: A total of 134 incident CHD events occurred during follow-up [45 nonfatal myocardial infarctions, 79 fatal myocardial infarctions, and 10 coronary revascularizations]. RESULTS: The median follow-up was 12.3 yr. Age-adjusted CHD risk estimates were similar for the four highest total T quintiles relative to the lowest, suggesting a low threshold. In age-adjusted analyses, the lowest total T quintile ( This article was published in J Clin Endocrinol Metab and referenced in Biochemistry & Analytical Biochemistry

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