Author(s): Tanaka T, Nakashima T, Ueda T, Tomii K, Kouno I
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Abstract One-pot reactions of aldoses with L-cysteine methyl ester and o-tolyl isothiocyanate yielded methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbamoyl)-thiazolidine-4(R)-carboxylates. Direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses. The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor.
This article was published in Chem Pharm Bull (Tokyo)
and referenced in Organic Chemistry: Current Research