alexa Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach.


Chemical Sciences Journal

Author(s): Chande MS, Verma RS, Barve PA, Khanwelkar RR, Vaidya RB,

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Abstract Spiro derivatives of oxindole and isoxazole-5-one were synthesized by using Michael addition reaction, highlighting the regioselective approach towards the synthesis of Michael diadduct followed by condensation of Michael diadduct. The spiro compound 4 showed antitubercular activity against Mycobacterium tuberculosis H37Rv whereas spiro compound 9 possesses pronounced anticancer and antibacterial profile. This article was published in Eur J Med Chem and referenced in Chemical Sciences Journal

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