alexa Factors and strategies for improving buccal absorption of peptides.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Veuillez F, Kalia YN, Jacques Y, Deshusses J, Buri P

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Abstract Peptides and polypeptides have important pharmacological properties but only a limited number (e.g. insulin, oxytocin, vasopressin) have been exploited as therapeutics because of problems related to their delivery. The buccal mucosa offers an alternative route to conventional, parenteral administration. Peptides are generally not well absorbed through mucosae because of their molecular size, hydrophilicity and the low permeability of the membrane. Peptide transport across buccal mucosa occurs via passive diffusion and is often accompanied by varying degrees of metabolism. This review describes various approaches to improve the buccal absorption of peptides including the use of penetration enhancers to increase membrane permeability and/or the addition of enzyme inhibitors to increase their stability. Other strategies including molecular modification with bioreversible chemical groups or specific formulations such as bioadhesive delivery systems are also discussed.
This article was published in Eur J Pharm Biopharm and referenced in Journal of Addiction Research & Therapy

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