alexa Familial colon cancer syndromes: an update of a rapidly evolving field.


Journal of Gastrointestinal & Digestive System

Author(s): Patel SG, Ahnen DJ

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Abstract Colorectal cancer (CRC) is a major cause of morbidity and mortality in the world. Up to 30 \% of CRCs have evidence of a familial component, and about 5 \% are thought to be due to well-characterized inherited mutations. This review will focus on recent developments in the understanding of the individual hereditary CRC syndromes, including Lynch syndrome, familial CRC type X, familial adenomatous polyposis, MutYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, PTEN hamartomatous syndrome, and serrated polyposis syndrome. Advances within the area of hereditary colon cancer syndromes paint a picture of a rapidly moving, rapidly maturing, and increasingly collaborative field with many opportunities for ongoing research and development.
This article was published in Curr Gastroenterol Rep and referenced in Journal of Gastrointestinal & Digestive System

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