alexa Fast and reliable determination of voriconazole in human plasma by LC-APCI-MS MS.


Journal of Drug Metabolism & Toxicology

Author(s): Xiong X, Duan J, Zhai S, Wang L, Lan X, Xiong X, Duan J, Zhai S, Wang L, Lan X

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Abstract A fast and reliable liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) method was developed and validated for the quantification of voriconazole in human plasma. The proposed method was validated in a linear range of 50-10,000 ng/ml, and the total run time was 1.5 min. This method was successfully used to support routine therapeutic drug monitoring of voriconazole. This article was published in Biosci Biotechnol Biochem and referenced in Journal of Drug Metabolism & Toxicology

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