alexa Feasibility and tolerability of probiotics for prevention of antibiotic-associated diarrhoea in hospitalized US military veterans.
Food & Nutrition

Food & Nutrition

Journal of Probiotics & Health

Author(s): Safdar N, Barigala R, Said A, McKinley L

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Abstract BACKGROUND: Probiotics may be efficacious for the prevention of antibiotic-associated diarrhoea. The tolerability and acceptability of probiotics in an elderly US veteran population has not been assessed. PURPOSE: To undertake a randomized trial to determine the tolerability and acceptability of a probiotic, Florajen in an elderly population with multiple comorbidities. METHODS: Pilot randomized double-blind trial comparing a probiotic, Florajen to placebo for the prevention of antibiotic-associated diarrhoea in elderly hospitalized patients receiving antibiotics. RESULTS: Forty patients were enrolled and randomized. Antibiotic-associated diarrhoea occurred in 6/16 (37\%) in the placebo group and 4/23 (17\%) patients in the Florajen group, (RR 1.63, 95\% CI 0.73-3.65, P = 0.15). Florajen was well tolerated in the study population with no major side effects that necessitated discontinuation. CONCLUSIONS: In this pilot study, Florajen was well tolerated in an elderly population, all of whom were taking several other medications. A larger study is needed to determine the effect of Florajen on antibiotic-associated diarrhoea and Clostridium difficile infection. This article was published in J Clin Pharm Ther and referenced in Journal of Probiotics & Health

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