alexa Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Herold BC, Mesquita PM, Madan RP, Keller MJ, Herold BC, Mesquita PM, Madan RP, Keller MJ

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Abstract Pharmacologic strategies for the prevention of HIV include vaccines, post-exposure prophylaxis with antiretroviral therapy, and topical microbicides. Vaginal microbicides have the potential to augment innate defenses in the genital tract but may also disrupt endogenous protection and increase HIV acquisition risk, as observed in clinical trials of nonoxynol-9. The initially disappointing results of microbicide clinical trials stimulated the development of more sensitive and comprehensive pre-clinical safety studies, which include dual-chamber culture systems to model the epithelial barrier and post-coital studies to evaluate the effects of semen and sexual intercourse on microbicide efficacy. This review discusses the key factors that contribute to a healthy female genital tract environment, the impact of semen on mucosal defense, and how our understanding of these mediators informs the development of effective vaginal microbicides. © 2010 John Wiley & Sons A/S.
This article was published in Am J Reprod Immunol and referenced in Journal of AIDS & Clinical Research

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