Author(s): Vairaktaris E
BACKGROUND: FGFR-2 and FGFR-3 (fibroblast growth factor receptors) have been shown to play an important role in several processes including carcinogenesis. This study was designed to determine gradual FGFR-2 and FGFR-3 expression in sequential stages of oral carcinogenesis in an experimental animal system of Syrian golden hamsters. MATERIALS AND METHODS: Tissue sections ranging from normal mucosa to squamous cell carcinoma were studied using monoclonal antibodies against FGFR-2 and FGFR-3 proteins. RESULTS: A significant elevation was revealed in both FGFR-2 and FGFR-3 expression during the stages of dysplasia and early invasion, while in the later stages of oral carcinogenesis the expression of both FGFR-2 and FGFR-3 decreased although not significantly. CONCLUSION: Our findings indicate that FGFR-2 and FGFR-3 seem to play an important role in the initial stages of oral cancer progression.