alexa Fibrinolytic and fibrin stabilizing activity of synovial membranes.
Healthcare

Healthcare

Health Care : Current Reviews

Author(s): Salvi R, So A, Busso N, Pclat V

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Abstract

STATEMENT OF FINDINGS: We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue factor, tissue factor pathway inhibitor, urokinase plasminogen activator, and plasminogen activator inhibitor 1, as well as thrombin receptor. The observed pattern of gene expression tended to favor procoagulant activity, and this pattern was confirmed by functional assays. These alterations would account for persistence of fibrin within the inflamed joint, as is seen in rheumatoid arthritis.

This article was published in below Ann Rheum Dis and referenced in Health Care : Current Reviews

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