Author(s): Tran DT, Salmon R
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Abstract BACKGROUND: Diffuse field change with actinic keratoses (AK) is a ubiquitous skin disease in Australia, with potential for malignant transformation. We report on 35 consecutive patients who had field therapy with single session photodynamic therapy (PDT) using 1 h incubation time for 5-aminolevulinic acid (5-ALA) or 3 h for methyl-aminolevulinate (MAL). METHODS: We retrospectively telephone surveyed our patient cohort regarding their satisfaction and perceptions of the effectiveness, side-effect profile and benefits of PDT. We also reviewed all patients' notes for significant side-effects. RESULTS: Sixty-nine per cent (n = 24/35) of patients responded to the telephone survey; 66\% (n = 16/24) of the respondents reported good clearance of AK and claimed a good cosmetic outcome. All respondents reported moderate or severe pain (42\% and 58\%, respectively) during the illumination phase. Twenty per cent of all patients treated had suffered from one or more of the following side-effects: pustulation; severe erythema; and skin erosions. CONCLUSIONS: Overall, our results compared favourably with previously published studies using 5-ALA or MAL PDT. However, our patient cohort experienced a greater side-effect profile. This may have been due to our patients having greater disease burden compared to other studies and possibly due to our use of topical retinoids prior to PDT in selected patients. © 2011 The Authors; Australasian Journal of Dermatology © 2011 The Australasian College of Dermatologists.
This article was published in Australas J Dermatol
and referenced in Journal of Clinical & Experimental Dermatology Research