alexa Field-cycling NMR relaxometry with spatial selection.
Biomedical Sciences

Biomedical Sciences

Journal of Bioengineering & Biomedical Science

Author(s): Pine KJ, Davies GR, Lurie DJ

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Abstract Fast field-cycling MRI offers access to sources of endogenous information not available from conventional fixed-field imagers. One example is the T(1) dispersion curve: a plot of T(1) versus field strength. We present a pulse sequence that combines saturation-recovery/inversion-recovery T(1) determination with field cycling and point-resolved spectroscopy localization, enabling the measurement of dispersion curves from volumes selected from a pilot image. Compared with a nonselective sequence, our method of volume selection does not influence measurement accuracy, even for relatively long echo times and in the presence of radiofrequency field nonuniformity. The measured voxel profile, while not ideal, corresponds with that expected from the image slice profile. On a whole-body fast field-cycling scanner with 59-mT detection, the sensitivity of the experiment is sufficient to reveal distinctive "quadrupole dips" in dispersion curves of protein-rich human tissue in vivo. (c) 2010 Wiley-Liss, Inc. This article was published in Magn Reson Med and referenced in Journal of Bioengineering & Biomedical Science

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