alexa Field-effect control of protein transport in a nanofluidic transistor circuit
Chemical Engineering

Chemical Engineering

Journal of Analytical & Bioanalytical Techniques

Author(s): Rohit Karnik, Kenneth Castelino, Arun Majumdar

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Electrostatic interactions play an important role in nanofluidic channels when the channel size is comparable to the Debye screening length. Electrostatic fields have been used to control concentration and transport of ions in nanofluidictransistors. Here, we report a transistor-reservoir-transistor circuit that can be used to turn “on” or “off” protein transport using electrostatic fields with gate voltages of ±1V±1V. Our results suggest that global electrostatic interactions of the protein were dominant over other interactions in the nanofluidictransistor. The fabrication technique also demonstrates the feasibility of nanofluidic integrated circuits for the manipulation of biomolecules in picoliter volumes.

This article was published in Applied Physics Letters and referenced in Journal of Analytical & Bioanalytical Techniques

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