Author(s): Tennen RI, MichishitaKioi E, Chua KF
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Abstract Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1α. Copyright © 2012 Elsevier Inc. All rights reserved.
This article was published in Cell
and referenced in Journal of Antivirals & Antiretrovirals