alexa Fine tuning the pH triggers the enantiorecognition of underivatized amino acids by silver nanoparticles: a novel approach based on the focused use of solution equilibria.


Modern Chemistry & Applications

Author(s): Contino A, Maccarrone G, Zimbone M, Musumeci P, Calcagno L,

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Abstract Stereoselective amino acid analysis is still a challenging task. In this work, we report a study on the chiral recognition of D,L-Trp and D,L-His using L-Cys capped silver nanoparticles (AgNPs) and copper(II) ion. The AgNPs have been characterized by TEM, UV-Vis spectra and dynamic light scattering (DLS) measurements and used for chiral discrimination. In the L-Cys capped AgNPs, the α-amino and α-carboxyl groups of the surface-confined amino acid, besides showing either a negative or a neutral charge as a function of the pH, can coordinate the copper(II) ion, which in turn, binds the L- or D-amino acid present in solution forming diastereoisomeric complexes. The resulting systems have been characterized by UV-Vis spectroscopy, exploiting the zwitterionic nature of the cysteine to obtain enantiodiscrimination by a fine tuning of the pH. The analysis of the UV-Vis data by using a multiwavelength approach allows us to determine the kinetic constants ruling the processes. Copyright © 2014 Elsevier Inc. All rights reserved. This article was published in J Colloid Interface Sci and referenced in Modern Chemistry & Applications

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