alexa First and second order derivative spectrophotometric determination of benzyl alcohol and diclofenac in pharmaceutical forms.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): de Micalizzi YC, Pappano NB, Debattista NB

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Abstract Diclofenac sodium is a drug with analgesic, antipyretic and anti-inflammatory properties. It is present in numerous pharmaceutical preparations. In injectable forms, it is usually accompanied by benzyl alcohol as an excipient, which is used as a blocking anesthetic (4\%) and an antiseptic (4-10\%). In this work spectrophotometric methodology was used in order to determine diclofenac and benzyl alcohol in injectable formulations by applying, on the one hand, the first-derivative method of crossing zero for diclofenac sodium and on the other, second derivative for benzyl alcohol. The results obtained show that this method has a significant advantage over other techniques and it is appropriate for routine pharmaceutical analysis.
This article was published in Talanta and referenced in Pharmaceutica Analytica Acta

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