alexa First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil.


Journal of Neonatal Biology

Author(s): Calvet GA, Filippis AM, Mendona MC, Sequeira PC, Siqueira AM,

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Abstract Since May 2015, Brazil's Ministry of Health has reported autochthonous transmission of Zika virus (ZIKV) in some states of the country. Simultaneous circulation of Dengue, Chikungunya and ZIKV in the country hinder both the diagnosis and the therapeutic approach of patients seeking care with acute febrile illnesses especially in patients with comorbidities. The association between HIV infection and endemic diseases has been described especially in tropical regions with varying levels of complications, although there has been no report of ZIKV in HIV-infected patients. We report the first autochthonous case of laboratory confirmed ZIKV infection in a HIV-infected patient in Rio de Janeiro, Brazil. He evolved with only mild symptoms and recovered well without major laboratory abnormalities. Phylogenetic analysis of the ZIKV detected in the patient sera clustered within the Asian clade. To the best of our knowledge, this is the first time that Zika virus co-infection is reported in a HIV-infected patient. Copyright © 2015 Elsevier B.V. All rights reserved. This article was published in J Clin Virol and referenced in Journal of Neonatal Biology

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