alexa Five year outcomes of a cohort of HIV-infected injection drug users in a primary care practice.


Journal of Clinical Toxicology

Author(s): Fingerhood M, Rastegar DA, Jasinski D

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Abstract Overall mortality related to HIV infection has declined with the advent of highly active anti-retroviral therapy (HAART). The purpose of this study was to examine the five-year outcomes of a cohort of 175 consecutive patients with HIV infection and injection drug use followed at a primary care practice. Patients were seen for their first visit between June 1994 and May 1998. At five years from their initial visit, 53 patients (30.3\%) had died, while 47 (26.9\%) were still active patients in our primary care practice. Of those who died, HIV was the cause of death in a little over half of patients (55\%) followed by liver disease (15\%) and drug overdose (11\%). Only 80 patients ever received highly active anti-retroviral therapy (HAART) and 52 (65\%) of these achieved an undetectable viral load. Patients who never received HAART had a five-year mortality of 34.8\%, compared to 25.0\% in patients who ever received HAART, p < .001. Our data underscore the high burden of morbidity and mortality associated with HIV infection among IDUs despite the availability of effective treatment. This article was published in J Addict Dis and referenced in Journal of Clinical Toxicology

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