alexa Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites.
Toxicology

Toxicology

Journal of Drug Metabolism & Toxicology

Author(s): Mahmoud YA, Assawah SW, ElSharkawy SH, AbdelSalam A

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Abstract Aspergillus niger isolated from Allium sativum was used at large scale fermentation (150 mg flavone/200 ml medium) to obtain suitable amounts of the products, efficient for identification. Then spectral analysis (UV, IR, (1)H-NMR, (13)C-NMR) and mass spectrometry were performed for the two products, which contributed to the identification process. The metabolite (1) was identified as 2'-hydroxydihydrochalcone, and the metabolite (2) was identified as 2'-hydroxyphenylmethylketone, which were more active than flavone itself. Antioxidant activities of the two isolated metabolites were tested compared with ascorbic acid. Antioxidant activity of metabolite (1) was recorded 64.58\% which represented 79\% of the antioxidant activity of ascorbic acid, and metabolite (2) was recorded 54.16\% (67\% of ascorbic acid activity). However, the antioxidant activity of flavone was recorded 37.50\% which represented 46\% of ascorbic acid activity. The transformed products of flavone have antimicrobial activity against Pseudomonas aeruginosa, Aspergillus flavus and Candida albicans, with MIC was recorded 250 µg/ml for metabolite (2) against all three organism and 500, 300, and 300 µg/ml for metabolite (1) against tested microorganisms (P. aeruginosa, Escherichia coli, Bacillus subtilis, and Klebsiella pneumonia, Fusarium moniliforme, A. flavus, Saccharomyces cerviceae, Kluveromyces lactis and C. albicans) at this order.
This article was published in Mycobiology and referenced in Journal of Drug Metabolism & Toxicology

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