alexa Flow-injection spectrophotometric determination of paracetamol in tablets and oral solutions.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Knochen M, Giglio J, Reis BF

Abstract Share this page

Abstract A flow injection method is proposed for the determination of paracetamol in pharmaceutical dosage forms. The method is based on the nitration of paracetamol with sodium nitrite, and the absorption of the reaction product is measured at 430 nm in alkaline medium. Unlike other colorimetric methods used for determination of paracetamol, this method does not require the use of heat. The influence of several operating parameters is studied. The method was applied to the determination of paracetamol in oral solutions and in tablets, alone or associated with caffeine. When the results were compared with those obtained by the official HPLC method (USP 24) the relative differences found were from 0.4 to 2.3\%, with relative standard deviations below 1\%.
This article was published in J Pharm Biomed Anal and referenced in Pharmaceutica Analytica Acta

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords