alexa Fluorinated amino acids: compatibility with native protein structures and effects on protein-protein interactions.
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Salwiczek M, Nyakatura EK, Gerling UI, Ye S, Koksch B

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Abstract Fluorinated analogues of the canonical α-L-amino acids have gained widespread attention as building blocks that may endow peptides and proteins with advantageous biophysical, chemical and biological properties. This critical review covers the literature dealing with investigations of peptides and proteins containing fluorinated analogues of the canonical amino acids published over the course of the past decade including the late nineties. It focuses on side-chain fluorinated amino acids, the carbon backbone of which is identical to their natural analogues. Each class of amino acids--aliphatic, aromatic, charged and polar as well as proline--is presented in a separate section. General effects of fluorine on essential properties such as hydrophobicity, acidity/basicity and conformation of the specific side chains and the impact of these altered properties on stability, folding kinetics and activity of peptides and proteins are discussed (245 references). This article was published in Chem Soc Rev and referenced in Biochemistry & Analytical Biochemistry

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