alexa Fluorine in medicinal chemistry.
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Purser S, Moore PR, Swallow S, Gouverneur V

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Abstract It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency. This article was published in Chem Soc Rev and referenced in Biochemistry & Analytical Biochemistry

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