alexa Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter
Microbiology

Microbiology

Clinical Microbiology: Open Access

Author(s): ALEXANDER A NEYFAKH, CARINA M BORSCH, GLENN W KAATZ

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The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

This article was published in Antimicrob Agents Chemother and referenced in Clinical Microbiology: Open Access

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