alexa Focal adhesion molecules as potential target of lead toxicity in NRK-52E cell line.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Giuliani R, Bettoni F, Leali D, Morandini F, Apostoli P,

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Abstract In this study, we investigated the influence of inorganic lead (Pb(II)), an environmental pollutant having nephrotoxic action, on the focal adhesion (FA) organization of a rat kidney epithelial cell line (NRK-52E). In particular, we evaluated the effects of the metal on the recruitment of paxillin, focal adhesion kinase, vinculin and cytoskeleton proteins at the FAs complexes. We provided evidences that, in proliferating NRK-52E cell cultures, low concentrations of Pb(II) affect the cell adhesive ability and stimulate the disassembly of FAs, thus inhibiting the integrin-activated signalling. These effects appeared to be strictly associated to the Pb-induced arrest of cell cycle at G0/G1 phase also proved in this cell line. This article was published in FEBS Lett and referenced in Journal of Cytology & Histology

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