alexa Folate fortification of rice by metabolic engineering.
Genetics & Molecular Biology

Genetics & Molecular Biology

Cloning & Transgenesis

Author(s): Storozhenko S, De Brouwer V, Volckaert M, Navarrete O, Blancquaert D,

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Abstract Rice, the world's major staple crop, is a poor source of essential micronutrients, including folates (vitamin B9). We report folate biofortification of rice seeds achieved by overexpressing two Arabidopsis thaliana genes of the pterin and para-aminobenzoate branches of the folate biosynthetic pathway from a single locus. We obtained a maximal enhancement as high as 100 times above wild type, with 100 g of polished raw grains containing up to four times the adult daily folate requirement. This article was published in Nat Biotechnol and referenced in Cloning & Transgenesis

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