alexa Food increases the bioavailability of acitretin.
General Science

General Science

Research & Reviews: Journal of Botanical Sciences

Author(s): McNamara PJ, Jewell RC, Jensen BK, Brindley CJ, McNamara PJ, Jewell RC, Jensen BK, Brindley CJ, McNamara PJ, Jewell RC, Jensen BK, Brindley CJ, McNamara PJ, Jewell RC, Jensen BK, Brindley CJ

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Abstract Eighteen healthy male volunteers received 50 mg oral doses of acitretin on two occasions, according to a random crossover design. Acitretin was administered during a complete fast or following a moderate breakfast. Plasma samples were obtained at various times and the concentration of acitretin and its 13-cis isomeric metabolite (Ro 13-7652) were quantified by a specific HPLC assay. The AUC0-15 for acitretin was increased when administered with food for all subjects (except one) with a mean increase of 90\% (from 1175 to 2249 ng/ml.hr). The maximum plasma concentration of acitretin (Cmax) was increased by 70\% when administered with food (from 245 to 416 ng/ml), while the time to reach Cmax was unaffected. The ratio of AUC of Ro 13-7652 to acitretin was the same for both the fasted and fed conditions; therefore, the formation of metabolite was not influenced by concomitant ingestion of food. The presence of food increases the apparent bioavailability of acitretin. A likely mechanism behind this observation is an increase in acitretin solubility in addition to an increase in the lymphatic absorption and a prolonged residence time of the drug in the gastrointestinal tract.
This article was published in J Clin Pharmacol and referenced in Research & Reviews: Journal of Botanical Sciences

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