alexa Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis.
Healthcare

Healthcare

Journal of Community Medicine & Health Education

Author(s): Bazhan N, Zelena D

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Abstract The prevalence of obesity is increasing worldwide with serious consequences such as diabetes mellitus type 2 and cardiovascular diseases. Emotional stress is considered to be one of the main reasons of obesity development in humans. However, there are some contradictory results, which should be addressed. First of all stress induces anorexia, but not overeating in laboratory animals. Glucocorticoids, the effector molecules of the hypothalamo-pituitary-adrenocortical (HPA) axis stimulate and stress inhibits food intake. It is also not clear if stress is diabetogenic or an antidiabetogenic factor. The review will discusses these issues and the involvement of the whole HPA axis and its separate molecules (glucocorticoids, adrenocorticotropin, corticotropin-releasing hormone) in food intake regulation under stress. Copyright © 2013 Elsevier Inc. All rights reserved. This article was published in Brain Res Bull and referenced in Journal of Community Medicine & Health Education

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