alexa Formaldehyde exposure and asthma in children: a systematic review.
Toxicology

Toxicology

Journal of Environmental & Analytical Toxicology

Author(s): McGwin G, Lienert J, Kennedy JI, McGwin G, Lienert J, Kennedy JI

Abstract Share this page

Abstract OBJECTIVE: Despite multiple published studies regarding the association between formaldehyde exposure and childhood asthma, a consistent association has not been identified. Here we report the results of a systematic review of published literature in order to provide a more comprehensive picture of this relationship. DATA SOURCES: After a comprehensive literature search, we identified seven peer-reviewed studies providing quantitative results regarding the association between formaldehyde exposure and asthma in children. Studies were heterogeneous with respect to the definition of asthma (e.g., self-report, physician diagnosis). Most of the studies were cross-sectional. DATA EXTRACTION: For each study, an odds ratio (OR) and 95\% confidence interval (CI) for asthma were either abstracted from published results or calculated based on the data provided. Characteristics regarding the study design and population were also abstracted. DATA SYNTHESIS: We used fixed- and random-effects models to calculate pooled ORs and 95\% CIs; measures of heterogeneity were also calculated. A fixed-effects model produced an OR of 1.03 (95\% CI, 1.021.04), and random effects model produced an OR of 1.17 (95\% CI, 1.011.36), both reflecting an increase of 10 microg/m3 of formaldehyde. Both the Q and I2 statistics indicated a moderate amount of heterogeneity. CONCLUSIONS: Results indicate a significant positive association between formaldehyde exposure and childhood asthma. Given the largely cross-sectional nature of the studies underlying this meta-analysis, further well-designed prospective epidemiologic studies are needed.
This article was published in Environ Health Perspect and referenced in Journal of Environmental & Analytical Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords