alexa Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70.


Journal of Cancer Science & Therapy

Author(s): Weinstock DM, Brunet E, Jasin M

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Abstract Chromosomal translocations in lymphoid tumours can involve antigen-receptor loci undergoing V(D)J recombination. Here, we show that translocations are recovered from the joining of RAG-generated double-strand breaks (DSBs) on one chromosome to an endonuclease-generated DSB on a second chromosome, providing evidence for the participation of non-RAG DSBs in some lymphoid translocations. Surprisingly, translocations are increased in cells deficient for the nonhomologous end-joining (NHEJ) protein Ku70, implicating non-canonical joining pathways in their etiology.
This article was published in Nat Cell Biol and referenced in Journal of Cancer Science & Therapy

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