Author(s): Sankar V, Praveen C, Prasanth KG, Srinivas CR, Ruckmann K
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Abstract Proniosomes, a novel drug delivery approach for increasing permeation of hydrocortisone through the skin, were investigated. Proniosome hydrocortisone gel was prepared by a coacervation-phase separation method using different combinations of non-ionic surfactants with cholesterol and lecithin. Proniosome formulations were characterized for vesicle size, entrapment efficiency, and drug content uniformity. Span 20:Span 40, Span 20:Span 60 and Span 20:Span 80 combinations showed good entrapment compared with Span: Tween combinations (Span 20:Tween 40, Span 20:Tween 60, Span 20:Tween 80). In vitro release in 8h from a Span 20:Span 80 proniosome 1\% hydrocortisone formulation was high (58.29 \%) compared to the other proniosome formulations. Proniosome hydrocortisone gel shows diffusion type release which was confirmed by Higuchi and Peppas plot. In vivo studies in mice confirmed that the proniosome 1\% hydrocortisone formulation was more active than a commercially marketed 1\% hydrocortisone cream. Topical application of hydrocortisone in the form of proniosomes leads to prolonged action.
This article was published in Pharmazie
and referenced in Journal of Addiction Research & Therapy