Author(s): GuzmanVillanueva D, ElSherbiny IM, HerreraRuiz D, Vlassov AV, Smyth HD
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Abstract RNA interference has emerged as a potentially powerful tool in the treatment of genetic and acquired diseases by delivering short interfering RNA (siRNA) or microRNA (miRNA) to target genes, resulting in their silencing. However, many physicochemical and biological barriers have to be overcome to obtain efficient in vivo delivery of siRNA and miRNA molecules to the organ/tissue of interest, thereby enabling their effective clinical therapy. This review discusses the challenges associated with the use of siRNA and miRNA and describes the nonviral delivery strategies used in overcoming these barriers. More specifically, emphasis has been placed on those technologies that have progressed to clinical trials for both local and systemic siRNA and miRNA delivery. Copyright © 2012 Wiley Periodicals, Inc.
This article was published in J Pharm Sci
and referenced in Journal of Microbial & Biochemical Technology