Author(s): Abdelwahed W, Degobert G, Stainmesse S, Fessi H
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Abstract Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanoparticles. This article reviews the state of the art of freeze-drying nanoparticles. It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nanoparticles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability.
This article was published in Adv Drug Deliv Rev
and referenced in Journal of Nanomedicine & Nanotechnology