alexa From lab to bedside: emerging clinical applications of thymosin alpha 1.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Goldstein AL, Goldstein AL

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Abstract BACKGROUND: Thymosin alpha(1) (Talpha(1)), a synthetic version of a thymic-derived biological response modifier was the first of the thymosins in clinical use. Talpha(1) is approved in over 35 countries for the treatment of hepatitis B and C, and as an immune stimulant and adjuvant. Talpha(1) is also in late-stage clinical testing in the United States and Europe for hepatitis C and stage IV melanoma. OBJECTIVE/METHODS: Novel applications and other recently completed trials point to much broader clinical applications of Talpha(1) in the treatment of life-threatening and chronic diseases, and are the subject of this review. RESULT/CONCLUSIONS: The most recent reports of clinical trials with Talpha(1) are pointing to important, hitherto unrecognized, applications in a number of diseases and disorders, including septic shock, acute respiratory distress syndrome, peritonitis, acute cytomegalovirus infection, TB, severe acute respiratory syndrome, and lung infections in critically ill patients. It is also emerging as a promising chemoprotection agent in patients undergoing chemotherapy. This article was published in Expert Opin Biol Ther and referenced in Journal of Clinical & Experimental Pharmacology

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