alexa Fucoxanthin derivatives from Sarggassum siliquastrum inhibit matrix metalloproteinases by suppressing NF-κB and MAPKs in human fibrosarcoma cells
Geology & Earth Science

Geology & Earth Science

Journal of Oceanography and Marine Research

Author(s): VanTinh Nguyen, ZhongJi Qian, Bonggi Lee, SooJin Heo, KilNam Kim

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Fucoxanthin is known to be an effective cell proliferation inhibitor with anti-tumor and anti-angiogenic activities. However, there is a lack of data regarding the biological effects of cis isomers of fucoxanthin. To assess the potential therapeutic properties of 9′- cis -(6′ R ) fucoxanthin (FcA), and 13- cis and 13′- cis -(6′ R ) fucoxanthin complex (FcB) isolated from Sarggassum siliquastrum , we investigated their inhibitory effects on matrix metalloproteinases (MMPs) in phorbol 12-myristate 13-acetate (PMA)-induced human fibrosarcoma (HT1080) cells. FcA and FcB reduced MMP-2 and MMP-9 protein and mRNA levels, as well as the migration of these cells, in a dose-dependent manner. Additionally, FcA and FcB increased levels of MMPs inhibition factors such as tissue inhibitor of metalloproteinase-1. FcA and FcB significantly inhibited the transcriptional activity of nuclear factor кB (NF-кB) and by inhibiting c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. Our results demonstrate that suppression of the NF-κB, JNK, and p38 signaling pathways may inhibit PMA-induced MMP-2 and MMP-9 activity. Therefore, FcA and FcB may be useful in noninvasive therapeutic strategies against fibrosarcoma metastasis.

This article was published in ALGAE and referenced in Journal of Oceanography and Marine Research

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